Toshifumi tanabu biography channel
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pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 2. Functional aspects.
PubMed
Tirupula, Kalyan C; Balem, Fernanda; Yanamala, Naveena; Klein-Seetharaman, Judith
2009-01-01
Anthocyanins are a class of phytochemicals that confer color to flowers, fruits, vegetables and leaves. They are part of our regular diet and serve as dietary supplements because of numerous health benefits, including improved vision. Recent studies have shown that the anthocyanin cyanidin-3-O-glucoside (C3G) increased regeneration of the dim-light photoreceptorrhodopsin (Matsumoto et al. [2003] J. Agric. Food Chem., 51, 3560-3563). In an accompanying study (Yanamala et al. [2009] Photochem. Photobiol.), we show that C3G directly binds to rhodopsin in a pH-dependent manner. In this study, we investigated the functional consequences of C3G binding to rhodopsin. As observed previously in rod outer segments, regeneration of purified rhodopsin in detergent micelles is also accelerated in the presence of C3G. Thermal denaturation and stability studies using circular dichroism, fluorescence and UV/visible absorbance spectroscopy show that C3G exerts a destabilizing effect on rhodopsin structure while it only modestly alters G-protein activation and the rates at which the light-activated Metarh
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Refill Magazine 4
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23/9/04
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Refill ZeroFour Contents
Issue4_layout14_NEWFONT
INKHEADS RAY PARLA WONDERWALL ANDY HOWELL MAINFRAME SSUR INVISIBLE MAN IOSIF KIRALY
124 126 134 138 144 150 156 162
OUR SPOT DEVILOCK HANON SHOP DALEK JAKE CHRIS SILVA MIKE GENOVESE LINDA GREGORIOU
168 174 180 186 192
FUDGE FACTORY COMICS MARK BODE MEPHISTO JONES GWG INDEX
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