Meghna patel biography template
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Published in final edited form as: Int J Cancer. 2011 Feb 1;128(3):587–596. doi: 10.1002/ijc.25388
Abstract
Members of the polo-like kinases (Plk1, Plk2, Plk3, and Plk4) are involved in the regulation of various stages of the cell cycle and have been implicated in cancer progression. Unlike its other family members the expression of Plk3 remains steady during cell cycle progression, suggesting that its activity may be spatiotemporally regulated. However, the mechanism of regulation of Plk3 activity is not well understood. Here, we show that calcium- and integrin-binding protein 1 (CIB1), a Plk3 interacting protein, is widely expressed in various cancer cell lines. Expression of CIB1 mRNA as well as protein is increased in breast cancer tissue as compared to normal tissue. CIB1 constitutively interacts with Plk3 as determined by both in vitro and in vivo assays. This interaction of CIB1 with Plk3 is independent of intracellular Ca2+. Furthermore, binding of CIB1 results in inhibition of Plk3 kinase activity both in vitro and in vivo. Interestingly, this inhibition of the Plk3 activity by CIB1 is Ca2+-dependent. Taken together, our results suggest that CIB1 is a regulatory subunit of Plk3 and it regulates Plk3 a
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Joep beving biography templates
Dutch composer and pianist
Musical artist
Joep Beving (born 9 January 1976 in Doetinchem) is a Dutch composer and pianist.[1][2][3]
Life and work
Music has been a passion of Beving’s since childhood.
The son of a schoolteacher, he formed his first band at the age of 14. He later won a place at a conservatoire, but repetitive strain injury to his wrist forced him to abandon his piano studies after a year.
Joep beving biography templates
Instead, he studied public policy and administration.
He then went to work in the advertising business, where he was mainly responsible for the music of numerous commercials. He also composed soundtracks for the short filmsHortum (2010) and Het cadeau (2015).[1]
In 2015 Beving released his first album - Solipsism, with modern classical atmospheric piano pieces.
He himself describes his compositions as "accessible music for complex emotions".[4] In 2017 his second album, Prehension, appeared in a simi
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